Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate CAS

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate CAS Number 159857-81-5 Related CAS Molecular Formula C35H43N7O11 Molecular Weight 737

64 SMILES Cl

originally isolated from Rhodococcus rhodochrous

5-FAM alkyne is an excellent azide-reactive fluorescent reagent for labeling alkyne-containing biological molecules through click chemitry

Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate CASSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate