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Product Name 2-Chloro-6-methyl-N
265 Purity (HPLC) >= 95% Solubility DMSO
Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500
the reaction product is stable
Azide-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg Product Name 2-Chloro-6-methyl-NSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing
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